Selected publications

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse - Conway JRW, Warren SC, Lee Y-K, McCulloch AT, Magenau A, Lee V, Metcalf XL, Stoehr J, Haigh K, Abdulkhalek L, Guaman CS, Reed DA, Murphy KJ, Pereira BA, Mélénec P, Chambers C, Latham SL, Lenthall H, Deenick EK, Ma Yuanging, Phan T, Lim E, Joshua AM, Walters S, Grey ST, Shi Y-C, Zhang L, Herzog H, Croucher DR, Philp A, Scheele CLGJ, Herrmann D, Sansom AJ, Morton JP, Papa A, Haigh JJ, Nobis M, Timpson P - Science Advances - Pubmed

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression - Hutten SJ, de Bruijn R, Lutz C, Badoux M, Eijkman T, Chao X, Ciwinska M, Sheinman M, Messal H, Herencia-Ropero A, Kristel P, Mulder L, can der Waal R, Sanders J, Almekinders MM, Llop-Guevara A, Davies HR, van Haren MJ, Martin NI, Behbod F, Nik-Zainal S, Serra V, van Rheenen J, Lips EH, Wessels LFA, Grand Challenge PRECISION Consortium, Wesseling J, Scheele CLGJ, Jonkers J - Cancer Cell - Pubmed

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer - Houthuijzen JM, de Bruijn R, van der Burg E, Drenth AP, Wientjens E, Filipovic T, Bullock E, Brambillasca CS, Pulver EM, Nieuwland M, de Rink I, van Diepen F, Klarenbeek S, Kerkhoven R, Brunton VG, Scheele CL, Boelens MC, Jonkers J - Nature Communications - Pubmed

Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis - Fankhaenel M, Hashemi FSG, Mourao L, Lucas E, Hosawi MM, Skipp P, Morin X, Scheele CL, Elias S - Nature Communications - Pubmed

 A guide toward multi-scale and quantitative branching analysis in the mammary gland - Hannezo E, Scheele CL - Methods in Molecular Biology - Pubmed

MYO10-filopodia support basement membranes at pre-invasive tumor boundaries - Peuhu E, Jacquemet G, Scheele CL, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J. - Developmental Cell - Pubmed

Multidimentional imaging of breast cancer - Rios AC, van Rheenen J, Scheele CL - Cold Spring Harbour Perspective in Medicine - Pubmed

A Mammary Organoid Model to Study Branching Morphogenesis - Caruso M, Huang S, Mourao L, Scheele CLGJ - 2022 - Frontiers in Physiology - Pubmed

Longitudinal Intravital Microscopy using a Mammary Imaging Window with Replaceable Lid - Mourao L, Ciwinska M, van Rheenen J, Scheele CLGJ - 2022 - Journal of Visualized Experiments - Pubmed

Single cell analysis of regions of interest (SCARI) using a photosensitive tag - Van der Leun A, Hoekstra M, Reinalda L, Scheele CLGJ, Toebes M, van de Graaff M, Chen LYY, Li H, Bercovich A, Lubling Y, David E, Thommen D, Tanay A, van Rheenen J, Amit I, van Kasteren S, Schumacher T - 2021 - Nat Chem Biol - PubMed

Intravital microscopy to illuminate cell state plasticity during metastasis - Van Rheenen, J, Scheele, CLGJ - 2021 - Curr Opin Cell Biol - PubMed

An intravital microscopy toolbox to study mammary gland dynamics from cellular level to organ scale - Messal HA, van Rheenen, J, Scheele CLGJ - 2021 - J Mammary Gland Biol - PubMed

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis - Li L, Ugalde AP, Scheele CLGJ, Dieter SM, Nagel R, Ma J, Pataskar A, Korkmaz G, Elkon R, Chien MP, You L, Su PR, Bleijerveld OB, Altelaar M, Momchev L, Manber Z, Han R, van Breugel PC, Lopes R, Ten Dijke P, van Rheenen J, Agami R - 2021 - Genome Biology - Pubmed

Targeting dormant tumor cells to prevent cancer recurrence - Damen MPF, van Rheenen J, Scheele CLGJ - 2021 - FEBS Journal - PubMed

Capturing stem cell behavior using intravital and live cell microscopy - Fumagalli A, Bruens L, Scheele CLGJ#, van Rheenen J# - 2020 - Cold Spring Harbor Perspectives in Biology - PubMed

Stem cell lineage survival as a noisy competition for niche access. - Corominas-Murtra B, Scheele CLGJ, Kishi K, Ellenbroek SIJ, Simons BD, van Rheenen J, Hannezo E. - 2020 - Proc Natl Acad Sci USA - PubMed

A unifying theory of branching morphogenesis - Hannezo E*, Scheele CLGJ*, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD - 2017 - Cell - Pubmed

Identity and dynamics of mammary stem cells during branching morphogenesis - Scheele CLGJ*, Hannezo E*, Muraro MJ, Zomer A, Langedijk NSM, van Oudenaarden A, Simons BD, van Rheenen J - 2017 - Nature - Pubmed

Intravital insights into heterogeneity, metastasis, and therapy responses - Scheele CLGJ*, Maynard C*, van Rheenen J - 2016 - Trends in Cancer - Pubmed

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion - Vellinga TT, den Uil S, Rinkes IHB, Marvin D, Ponsioen B, Alvarez-Varela A, Fatrai S, Scheele C, Zwijnenburg DA, Snippert H, Vermeulen L, Medema JP, Stockmann HB, Koster J, Fijneman RJA, de Rooij J, Kranenburg O - 2016 - Oncogene - Pubmed

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 - Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone G, Schulte-Merker S, de Bruin A - 2012 - EMBO Journal - Pubmed