Selected publications

Autophagy maintains high endothelial venule identity and function during inflammation - Jacobs KA, Hua Y, Nikolakopoulos AP, Gupta W, Vella G, Domingues Laranjeiro AF, Bonnereau J, Guyot M, Sassano ML, Mourao L, Cansiz F, Allies G, Van Baren N, Lucas S, Kawashima H, Sondermann W, Rambow F, Tasdogan A, Scheele C, Agostinis P, Bergers G - Immunity - Pubmed

Aneuploidy selects for the acquisition of driver genes in beast cancer - Al-Zahrani KN, Langille ER, Nurtanto J, Obersterescu A, Teng K, Lowden C, Dessapt J, Chiu CH, Caldwell LV, Cook DP, Pérez-Castro MA, Berman JM, Tsai R, Bahcheli AT, Mbamalu G, Wu S, Narimatsu M, Lopes AG, Fotaidou I, Chan K, Zhang L, Bang KWA, Parsons MJ, Mourao L, Temel EI, McCulla L, Sravya P, Zhang L, Sajjakulnukit P, Lyssiotis CA, Borowsky AD, Scheele CLGJ, Wahl DR, Jackson HW, Stewart KS, Fuchs E, Egan SE, Pujana MA, Reimand J, Wrana JL, Schramek D - Nature - Pubmed

Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis - Van Melkebeke L, Boesch M, Ostyn T, Huang W, Akkaya C, van Sligtenhorst M, El Abyad D, Safaeifard F, Dumarey A, Wallays M, Boeckx B, Feio-Azevedo R, Smets L, Gustot T, Trepo E, Moreno Ch, Putignano A, Lasser L, Colle I, Deltenre P, Marot A, Topal B, Claus E, Bonne L, Maleux G, Scheele C, Hendrikx T, Nevens F, Korf H, Roskams T, Denadai-Souza A, Lambrechts D, Govaere O, Van der Merwe S, Verbeek J - Journal of Hepatology - Pubmed

Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice - Koutsoumpou X, Lenders V, Krishnamoorthy AL, Vlaeminck I, Rozenski J, De Marco F, Rios Luci C, Roque Goncalves F, Girmatsion H, Ciwinska M, Nobis M, Scheele CLGJ, Soenen SJ, De Vleeschouwer, Manshian BB - Journal of Nanobiotechnology - Pubmed

Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma - Robatel S, Hillen H, Mutisheva I, Müller JC, Wartenberg M, Ma F, Bäriswyl L, Evenepoel J, Scheele CLGJ, Lee DJ, Modlin RL, Kessler U, Nobis M, Z'graggen K, Schenk M - Journal of Gastroenterology - Pubmed

Watching cancer begin: emerging tools to visualize the first steps of tumorigenesis - Messal HA, Mourao L, Dörner L, Scheele CLGJ, van Rheenen J - Trends in Cancer - Pubmed

Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies - Hutten SJ, Chao X, Badoux M, Eijkman T, Sheinman M, de Bruijn R, Herencia-Ropero A, Llop-Guevara A, Lutz C, Wesseling J, Serra V, van Rheenen J, Scheele CLJS, Jonkers J - Science Translational Medicine - Pubmed

Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State - El Laithy Y, Abreu de Olivera WA, Pabba A, Qualizza A, Cosemans G, Garcia-Diaz P, Richard F, Athanasouli P, Rios Luci C, De Wispelaere W, Mourao L, Hamer S, Moens S, De Jaime-Soguero A, Baietti MF, Hutten SJ, Jonkers J, Sammut S-J, Soenen S, Scheele CLGJ, Bruna A, Desmedt Ch, Annibali D, Lluis F - Cancer Research - Pubmed

Murine vascular organoids are responsive and adaptable 3D systems with cellular heterogeneity and dynamic plasticity - Guelfi S, Gopalan KS, Maene P, Robbert DJ, Pallarés-Mortalla C, Vella G, Nobis M, Mourao L, Bourdely P, van der Veer BK, Koh KP, Mazzone M, Scheele CLGJ, Bergers G, Science Advances - Pubmed

Jacaric Acid Empowers RSL3-Induced Ferroptotic Cell Death in Two- and Three-Dimensional Breast Cancer Cell Models - Cuvelier G, Vermonden P, Debisschop P, Martin M, Derouane F, Liebisch G, Ecker J, Hoering M, Berliere M, Van Bockstal M, Galant C, Duhoux F, Mourao L, Scheele C, Feron O, Rezsohazy R, Corbet C, Larondelle Y - International Journal of Molecular Sciences - Pubmed

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis - Smets L, Viola MF, Boesch M, Raman J, Van Melkebeke L, Nobis M, Flint E, Pajk N, Brescia P, Silvestri A, Feio-Azevedo R, Modave E, De Herdt L, Sanga A, Pop OT, Govaere O, Verbeek J, Denadai-Souza A, Cassiman D, Vandamme N, Boeckx B, Lambrechts D, Rescigno M, Bernsmeier Ch, Jones EAV, Hengstler JG, Ghallab A, Scheele CLGJ, Nevens F, Korf H, Boeckxtaens G, Van der Merwe SW - Gut - Pubmed

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy - Bornes L, van Winden LJ, Geurts VCM, de Bruijn B, Azarang L, Lanfermeijer M, Caruso M, Proost N, Boeije M, Lohuis JO, Belthier G, Noguera Delgado E, de Gruil N, Kroep JR, van de Ven M, Menezes R, Wesseling J, Kok M, Linn S, Broeks A, van Rossum HH, Scheele CLGJ, van Rheenen J. Nature – pubmed 
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Aspartate signalling drives lung metastasis via alternative translation - Doglioni G, Fernandez-Garcia J, Igelmann S, Alteo-Manzano P, Blomme A, La Rovere R, Liu X-Z, Liu Y, Tricot T, Nobis M, Leclercq M, El Kharraz S, Karras P, Hsieh Y-H, Solari F, Fiorella A, Martins Nascentes Melo L, Allies G, Scopelliti A, Rossi M, Vermeire I, BroekaertD, Ferreiro Campos AM, Neven P, Maetens M, Van Baelen K, Alkan HF, Planque M, Floris G, Sickmann A, Tasdogan A, Marine J-C, Scheele CLGJ, Desmedt C, Bultynck G, Close P, Fendt S-M - Nature - Pubmed 

Smad1/5 is acetylated in the dorsal aortae of the mouse embryo before the onset of blood flow, driving early arterial gene expression. Daems M, Ponomarev LC, Simoes-Faria R, Nobis M, Scheele CLGL, Luttun A, Ghesquière B, Zwijsen A, Jones EAV. Cardiovascular Research - Pubmed

Volumetric analysis of the terminal ductal lobular unit architecture and cell phenotypes in the human breast. Paavolainen O, Peurla M, Koskinen LM, Pohjankukka J, Saberi K, Tammelin E, Sulander SR, Valkonen M, Mourao L, Boström P, Brück N, Ruusuvuori P, Scheele CLGJ, Hartiala P, Peuhu E. Cell Reports - Pubmed

Mechanisms that clear mutations drive field cancerization in mammary tissue. Ciwinska M, Messal HA, Hristova HR, Lutz C, Bornes L, Chalkiadakis T, Harkes R, Langedijk NSM, Hutten SJ, Menezes RX, Jonkers J, Prekovic S, Grand Challenge PRECISION consortium, Simons BD, Scheele CLGJ, van Rheenen J. Nature - pubmed
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Research highlight

A Decision Tree to Guide Human and Mouse Mammary Organoid Model Selection. Caruso M, Saberiseyedabad K, Mourao L, Scheele CLGJ. Methods in Molecular Biology - Pubmed

Nanomaterial-Mediated Delivery of MLKL Plasmids Sensitizes Tumors to Immunotherapy and Reduces Metastases. Chu T, Maksoudian C, Pedrotti S, Izci M, Perez Gilabert I, Koutsoumpou X, Sargsian A, Girmatsion H, Goncalves FR, Scheele CL, Manshian BB, Soenen SJ. Advanced Healthcare Materials - Pubmed

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program. Geukens T, De Schepper M, Van Den Bogaert W, Van Baelen K, Maetens M, Pabba A, Mahdami A, Leduc S, Isnaldi E, Nguyen HL, Bachir I, Hajipirloo M, Zels G, Van Cauwenberge J, Borremans K, Vandecaveye V, Weynand B, Vermeulen P, Leucci E, Baietti MF, Sflomos G, Battista L, Brisken C, Derksen PWB, Koorman T, Visser D, Scheele CLGJ, Thommen DS, Hatse S, Fendt SM, Vanderheyden E, Van Brussel T, Schepers R, Boeckx B, Lambrechts D, Marano G, Biganzoli E, Smeets A, Nevelsteen I, Punie K, Neven P, Wildiers H, Richard F, Floris G, Desmedt C. NPJ Breast Cancer - Pubmed

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts. Hutten SJ, Messal HA, Lips EH, Sheinman M, Ciwinska M, Braams E, van der Borden C, Kristel P, Stoffers S, Wessels LF; Grand Challenge PRECISION Consortium; Jonkers J, van Rheenen J, Wesseling J, Scheele CL. The Journal of Pathology - Pubmed

Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers. Derouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C. Breast Cancer Research - Pubmed

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade. Houbaert D, Nikolakopoulos AP, Jacobs KA, Meçe O, Roels J, Shankar G, Agrawal M, More S, Ganne M, Rillaerts K, Boon L, Swoboda M, Nobis M, Mourao L, Bosisio F, Vandamme N, Bergers G, Scheele CLGJ, Agostinis P. Cell Reports - Pubmed

Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding. Riera-Domingo C, Leite-Gomes E, Charatsidou I, Zhao P, Carrá G, Cappellesso F, Mourao L, De Schepper M, Liu D, Serneels J, Alameh MG, Shuvaev VV, Geukens T, Isnaldi E, Prenen H, Weissman D, Muzykantov VR, Soenen S, Desmedt C, Scheele CLGJ, Sablina A, Di Matteo M, Martín-Pérez R, Mazzone M. Science Advances - Pubmed

Mouse intraductal modeling of primary ductal carcinoma in situ. Hutten SJ, Behbod F, Scheele CLGJ, Jonkers J. STAR Protocols - Pubmed

Multidimensional Imaging of Breast Cancer. Rios AC, van Rheenen J, Scheele CLGJ. Cold Spring Harb Perspectives in Medicine - Pubmed

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse - Conway JRW, Warren SC, Lee Y-K, McCulloch AT, Magenau A, Lee V, Metcalf XL, Stoehr J, Haigh K, Abdulkhalek L, Guaman CS, Reed DA, Murphy KJ, Pereira BA, Mélénec P, Chambers C, Latham SL, Lenthall H, Deenick EK, Ma Yuanging, Phan T, Lim E, Joshua AM, Walters S, Grey ST, Shi Y-C, Zhang L, Herzog H, Croucher DR, Philp A, Scheele CLGJ, Herrmann D, Sansom AJ, Morton JP, Papa A, Haigh JJ, Nobis M, Timpson P - Science Advances - Pubmed

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression - Hutten SJ, de Bruijn R, Lutz C, Badoux M, Eijkman T, Chao X, Ciwinska M, Sheinman M, Messal H, Herencia-Ropero A, Kristel P, Mulder L, can der Waal R, Sanders J, Almekinders MM, Llop-Guevara A, Davies HR, van Haren MJ, Martin NI, Behbod F, Nik-Zainal S, Serra V, van Rheenen J, Lips EH, Wessels LFA, Grand Challenge PRECISION Consortium, Wesseling J, Scheele CLGJ, Jonkers J - Cancer Cell - Pubmed

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer - Houthuijzen JM, de Bruijn R, van der Burg E, Drenth AP, Wientjens E, Filipovic T, Bullock E, Brambillasca CS, Pulver EM, Nieuwland M, de Rink I, van Diepen F, Klarenbeek S, Kerkhoven R, Brunton VG, Scheele CL, Boelens MC, Jonkers J - Nature Communications - Pubmed

Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis - Fankhaenel M, Hashemi FSG, Mourao L, Lucas E, Hosawi MM, Skipp P, Morin X, Scheele CL, Elias S - Nature Communications - Pubmed

 A guide toward multi-scale and quantitative branching analysis in the mammary gland - Hannezo E, Scheele CL - Methods in Molecular Biology - Pubmed

MYO10-filopodia support basement membranes at pre-invasive tumor boundaries - Peuhu E, Jacquemet G, Scheele CL, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J. - Developmental Cell - Pubmed

Multidimentional imaging of breast cancer - Rios AC, van Rheenen J, Scheele CL - Cold Spring Harbour Perspective in Medicine - Pubmed

A Mammary Organoid Model to Study Branching Morphogenesis - Caruso M, Huang S, Mourao L, Scheele CLGJ - 2022 - Frontiers in Physiology - Pubmed

Longitudinal Intravital Microscopy using a Mammary Imaging Window with Replaceable Lid - Mourao L, Ciwinska M, van Rheenen J, Scheele CLGJ - 2022 - Journal of Visualized Experiments - Pubmed

Single cell analysis of regions of interest (SCARI) using a photosensitive tag - Van der Leun A, Hoekstra M, Reinalda L, Scheele CLGJ, Toebes M, van de Graaff M, Chen LYY, Li H, Bercovich A, Lubling Y, David E, Thommen D, Tanay A, van Rheenen J, Amit I, van Kasteren S, Schumacher T - 2021 - Nat Chem Biol - PubMed

Intravital microscopy to illuminate cell state plasticity during metastasis - Van Rheenen, J, Scheele, CLGJ - 2021 - Curr Opin Cell Biol - PubMed

An intravital microscopy toolbox to study mammary gland dynamics from cellular level to organ scale - Messal HA, van Rheenen, J, Scheele CLGJ - 2021 - J Mammary Gland Biol - PubMed

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis - Li L, Ugalde AP, Scheele CLGJ, Dieter SM, Nagel R, Ma J, Pataskar A, Korkmaz G, Elkon R, Chien MP, You L, Su PR, Bleijerveld OB, Altelaar M, Momchev L, Manber Z, Han R, van Breugel PC, Lopes R, Ten Dijke P, van Rheenen J, Agami R - 2021 - Genome Biology - Pubmed

Targeting dormant tumor cells to prevent cancer recurrence - Damen MPF, van Rheenen J, Scheele CLGJ - 2021 - FEBS Journal - PubMed

Capturing stem cell behavior using intravital and live cell microscopy - Fumagalli A, Bruens L, Scheele CLGJ#, van Rheenen J# - 2020 - Cold Spring Harbor Perspectives in Biology - PubMed

Stem cell lineage survival as a noisy competition for niche access. - Corominas-Murtra B, Scheele CLGJ, Kishi K, Ellenbroek SIJ, Simons BD, van Rheenen J, Hannezo E. - 2020 - Proc Natl Acad Sci USA - PubMed

A unifying theory of branching morphogenesis - Hannezo E*, Scheele CLGJ*, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD - 2017 - Cell - Pubmed

Identity and dynamics of mammary stem cells during branching morphogenesis - Scheele CLGJ*, Hannezo E*, Muraro MJ, Zomer A, Langedijk NSM, van Oudenaarden A, Simons BD, van Rheenen J - 2017 - Nature - Pubmed

Intravital insights into heterogeneity, metastasis, and therapy responses - Scheele CLGJ*, Maynard C*, van Rheenen J - 2016 - Trends in Cancer - Pubmed

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion - Vellinga TT, den Uil S, Rinkes IHB, Marvin D, Ponsioen B, Alvarez-Varela A, Fatrai S, Scheele C, Zwijnenburg DA, Snippert H, Vermeulen L, Medema JP, Stockmann HB, Koster J, Fijneman RJA, de Rooij J, Kranenburg O - 2016 - Oncogene - Pubmed

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 - Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone G, Schulte-Merker S, de Bruin A - 2012 - EMBO Journal - Pubmed